ParkinsonCanadaV1, France, Analysis, bibRecord, 000179

Model-driven therapeutic treatment of neurological disorders: reshaping brain rhythms with neuromodulation

Identifieur interne : 000179 ( France/Analysis ); précédent : 000178; suivant : 000180

Model-driven therapeutic treatment of neurological disorders: reshaping brain rhythms with neuromodulation

Auteurs : Julien Modolo [Canada] ; Alexandre Legros [Canada] ; Alex W. Thomas [Canada] ; Anne Beuter [Canada, France]

Source :

Interface Focus [ 2042-8898 ] ; 2010.

RBID : PMC:3262241

Abstract

Electric stimulation has been investigated for several decades to treat, with various degrees of success, a broad spectrum of neurological disorders. Historically, the development of these methods has been largely empirical but has led to a remarkably efficient, yet invasive treatment: deep brain stimulation (DBS). However, the efficiency of DBS is limited by our lack of understanding of the underlying physiological mechanisms and by the complex relationship existing between brain processing and behaviour. Biophysical modelling of brain activity, describing multi-scale spatio-temporal patterns of neuronal activity using a mathematical model and taking into account the physical properties of brain tissue, represents one way to fill this gap. In this review, we illustrate how biophysical modelling is beginning to emerge as a driving force orienting the development of innovative brain stimulation methods that may move DBS forward. We present examples of modelling works that have provided fruitful insights in regards to DBS underlying mechanisms, and others that also suggest potential improvements for this neurosurgical procedure. The reviewed literature emphasizes that biophysical modelling is a valuable tool to assist a rational development of electrical and/or magnetic brain stimulation methods tailored to both the disease and the patient's characteristics.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262241

DOI: 10.1098/rsfs.2010.0509
PubMed: 22419974
PubMed Central: 3262241

Affiliations:

Canada, France

Links to Exploration step

PMC:3262241

Le document en format XML

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La maladie de Parkinson au Canada (serveur d'exploration)

Model-driven therapeutic treatment of neurological disorders: reshaping brain rhythms with neuromodulation

Model-driven therapeutic treatment of neurological disorders: reshaping brain rhythms with neuromodulation

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
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